Research At a Glance
- Research Category
- Tissue Repair & Recovery Research
- Peptide Length
- 15 amino acids (pentadecapeptide)
- Purity
- ≥ 99% (HPLC)
- Published Studies
- ~220 indexed
- Storage
- Lyophilized: 2–8 °C, protected from light. Reconstituted: 2–8 °C, use within 30 days.
Published-study figures are approximate PubMed result counts and indicate the volume of available literature only. Purity reflects third-party analytical testing on the corresponding lot; see the Quality Assurance Center for lot-matched certificates.
Overview
BPC-157’s research profile is distinguished by an unusually wide range of studied tissue types for a single peptide, spanning over three decades of primarily rodent-model literature from a research group at the University of Zagreb. Its stability in gastric acid and broad tissue-protective activity have made it a frequent reference compound in preclinical studies of healing, vascular recruitment, and cytoprotection.
Citation: Sikiric P., et al., Pharmaceuticals, 2024
History
BPC-157 was first described by Predrag Sikiric and colleagues in a 1993 paper in Journal de Physiologie (Paris), which proposed a “stomach-stress-organoprotection hypothesis” based on the peptide’s gastroprotective and stability properties. Early research focused on ulcer models, restraint stress, and chemically induced gastric lesions in rats. Over the following three decades, the research scope expanded substantially into vascular recruitment, wound healing, tendon and ligament injury, inflammatory bowel disease, and central nervous system models, with a 2024 review in Pharmaceuticals cataloguing over 130 published studies on the compound.
Citation: Sikiric P., et al., J Physiol Paris, 1993
Molecular Structure
| CAS # | 137525-51-0 |
|---|---|
| Molecular Formula | C62H98N16O22 |
| Molecular Weight | 1419.53 g/mol |
| PubChem CID | 9941957 |
| Classification | Synthetic pentadecapeptide (15 amino acids) |
| Format | Lyophilized powder |
| Purity | ≥99% (HPLC-verified per lot) |
| Storage | −20°C; refrigerate 2–8°C after laboratory handling |
Research Findings
BPC-157 has been studied in gastrointestinal, vascular, musculoskeletal, and neurological models, with reported activity in cytoprotection, angiogenesis, and tissue healing.
Key Areas of Research
- Gastrointestinal: Gastric and duodenal lesion protection, inflammatory bowel disease models, intestinal anastomosis and fistula healing
- Vascular: Angiogenesis, vascular recruitment, endothelial protection
- Musculoskeletal: Tendon, ligament, and muscle injury and healing models
- Neurological: Central nervous system injury models, reported interaction with neurotransmitter systems
Summary
Together, these findings position BPC-157 as one of the most broadly studied tissue-protective peptides in the preclinical literature, with research spanning organ systems that are rarely covered by a single compound. Despite this breadth, BPC-157 has not been approved by the FDA or other regulatory authorities for any human indication, and it was temporarily added to WADA’s monitoring list in 2022. The evidence base remains preclinical and rodent-derived.
Citation: Sikiric P., et al., Curr Pharm Des, 2018
Research Use Only
Provided for in-vitro laboratory research only. Not a drug, supplement, or cosmetic. Not for human or animal use.
Certificate of Analysis
Every lot is independently tested and lot-matched. View Certificates of Analysis
Related Research Categories
References
- Sikiric P., Petek M., Rucman R., et al. (1993). A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC. Journal de Physiologie (Paris).
- Sikiric P., Seiwerth S., Skrtic A., et al. (2018). Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing. Current Pharmaceutical Design.
- Sikiric P., Boban Blagaic A., Strbe S., et al. (2024). The Stable Gastric Pentadecapeptide BPC 157: Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity. Pharmaceuticals.