Research At a Glance
- Research Category
- Antimicrobial Peptide & Innate Immunity Research
- Peptide Length
- 37 amino acids (cathelicidin-derived)
- Purity
- ≥ 98% (HPLC)
- Published Studies
- 3,100+ indexed
- Storage
- Lyophilized: −20 °C long term, 2–8 °C short term. Reconstituted: 2–8 °C, use within 30 days.
Published-study figures are approximate PubMed result counts and indicate the volume of available literature only. Purity reflects third-party analytical testing on the corresponding lot; see the Quality Assurance Center for lot-matched certificates.
What It Is
A 37-amino-acid peptide (beginning with two leucine residues, hence “LL-37”) cleaved from the precursor protein hCAP18, produced by neutrophils, epithelial cells, and other immune cells as part of the innate immune response.
Research Mechanism
LL-37 has been studied for direct antimicrobial activity via membrane disruption of bacterial cell walls, as well as immunomodulatory roles including chemoattraction of immune cells and promotion of angiogenesis in wound-healing models (Dürr et al., 2006, review in Biochimica et Biophysica Acta — search PubMed ).
Research Applications
- Innate immunity and antimicrobial peptide research
- Wound healing and angiogenesis models
- Epithelial immune signaling research
Research Use Only
Provided for in-vitro laboratory research only. Not a drug, supplement, or cosmetic. Not for human or animal use.
Certificate of Analysis
Every lot is independently tested and lot-matched. View Certificates of Analysis